Rodney A. Bednar: search on Z-Library

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1

Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist

Libby, Brian E., Liverton, Nigel J., Bednar, Rodney A., Bednar, Bohumil, Butcher, John W., Claiborne, Christopher F., Claremon, David A., Cunningham, Michael, DiLella, Anthony G., Gaul, Stanley L.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 194 KB

english, 2007

2

Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists

Kevin T. Nguyen, Christopher F. Claiborne, John A. McCauley, Brian E. Libby, David A. Claremon, Rodney A. Bednar, Scott D. Mosser, Stanley L. Gaul, Thomas M. Connolly, Cindra L. Condra, Bohumil Bednar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

3

Potent benzimidazolone-based CGRP receptor antagonists

Cory R. Theberge, Rodney A. Bednar, Ian M. Bell, Halea A. Corcoran, John F. Fay, James C. Hershey, Victor K. Johnston, Stefanie A. Kane, Scott Mosser, Christopher A. Salvatore, Theresa M. Williams, C.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 220 KB

english, 2008

4

Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists

Charles J. McIntyre, John A. McCauley, Bohumil Bednar, Rodney A. Bednar, John W. Butcher, David A. Claremon, Michael E. Cunningham, Roger M. Freidinger, Stanley L. Gaul, Carl F. Homnick, Ken S. Koblan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 579 KB

english, 2009

5

3,4-Didehydro-2-ketoglutarate: an affinity label for DPN-dependent isocitrate dehydrogenase

Bednar, Rodney A., Hartman, Fred C., Colman, Roberta F.

Journal:

Year:

1982

Language:

english

File:

PDF, 991 KB

english, 1982

6

Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation

Egbertson, Melissa S., Cook, Jacquelynn J., Bednar, Bohumil, Prugh, John D., Bednar, Rodney A., Gaul, Stanley L., Gould, Robert J., Hartman, George D., Homnick, Carl F., Holahan, Marie A., Libby, Laur

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 151 KB

english, 1999

7

Fibrinogen Receptor Antagonist-Induced Thrombocytopenia in Chimpanzee and Rhesus Monkey Associated With Preexisting Drug-Dependent Antibodies to Platelet Glycoprotein IIb/IIIa

Bednar, Bohumil, Cook, Jacquelynn J., Holahan, Marie A., Cunningham, Michael E., Jumes, Patricia A., Bednar, Rodney A., Hartman, George D., Gould, Robert J.

Journal:

Year:

1999

File:

PDF, 453 KB

1999

8

Automation of In Vitro Dose-Inhibition Assays Utilizing the Tecan Genesis and an Integrated Software Package to Support the Drug Discovery Process

Mosser, Scott D., Gaul, Stanley L., Bednar, Bohumil, Koblan, Kenneth S., Bednar, Rodney A., Bednar, Rodney A.

Journal:

Journal of the Association for Laboratory Automation

Year:

2003

File:

PDF, 1.93 MB

2003

9

Identification of potent, highly constrained CGRP receptor antagonists

Craig A. Stump, Ian M. Bell, Rodney A. Bednar, John F. Fay, Steven N. Gallicchio, James C. Hershey, Richard Jelley, Constantine Kreatsoulas, Eric L. Moore, Scott D. Mosser, Amy G. Quigley, Shane A. Ro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 847 KB

english, 2010

10

NR2B-Selective N -Methyl- d -aspartate Antagonists: Synthesis and Evaluation of 5-Substituted Benzimidazoles

McCauley, John A., Theberge, Cory R., Romano, Joseph J., Billings, Susan B., Anderson, Kenneth D., Claremon, David A., Freidinger, Roger M., Bednar, Rodney A., Mosser, Scott D., Gaul, Stanley L., Conn

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 123 KB

english, 2004

11

The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists

Ian M. Bell, Rodney A. Bednar, Halea A. Corcoran, John F. Fay, Steven N. Gallicchio, Victor K. Johnston, James C. Hershey, Cynthia M. Miller-Stein, Eric L. Moore, Scott D. Mosser, Shane A. Roller, Chr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 806 KB

english, 2009

12

Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets

Bohumil Bednar, Michael E. Cunningham, Patricia A. McQueney, Melissa S. Egbertson, Benny C. Askew, Rodney A. Bednar, George D. Hartman, Robert J. Gould

Journal:

Cytometry Part A

Year:

1997

Language:

english

File:

PDF, 142 KB

english, 1997

13

Cover Picture: Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties (ChemMedChem 3/2012)

Dr. Paul J. Coleman, John D. Schreier, Dr. Christopher D. Cox, Michael J. Breslin, David B. Whitman, Dr. Michael J. Bogusky, Dr. Georgia B. McGaughey, Dr. Rodney A. Bednar, Wei Lemaire, Dr. Scott M. D

Journal:

Year:

2012

Language:

english

File:

PDF, 754 KB

english, 2012

14

Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality

Michael R. Wood, Kathy M. Schirripa, June J. Kim, Rodney A. Bednar, John F. Fay, Joseph G. Bruno, Eric L. Moore, Scott D. Mosser, Shane Roller, Christopher A. Salvatore, Joseph P. Vacca, Harold G. Sel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 719 KB

english, 2010

15

Preclinical pharmacology and pharmacokinetics of CERC-301, a GluN2B-selective N -methyl-D-aspartate receptor antagonist

Garner, Rachel, Gopalakrishnan, Shobha, McCauley, John A., Bednar, Rodney A., Gaul, Stanley L., Mosser, Scott D., Kiss, Laszlo, Lynch, Joseph J., Patel, Shil, Fandozzi, Christine, Lagrutta, Armando, B

Journal:

Pharmacology Research & Perspectives

Year:

2015

Language:

english

File:

PDF, 302 KB

english, 2015

16

The discovery of highly potent CGRP receptor antagonists

Craig A. Stump, Ian M. Bell, Rodney A. Bednar, Joseph G. Bruno, John F. Fay, Steven N. Gallicchio, Victor K. Johnston, Eric L. Moore, Scott D. Mosser, Amy G. Quigley, Christopher A. Salvatore, Cory R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 183 KB

english, 2009

17

Nonpeptide GPIIB/IIIA inhibitors. 16. Thieno[2,3-b]thiophene α-sulfonamides are potent inhibitors of platelet aggregation

John D. Prugh, Robert J. Gould, Robert J. Lynch, Guixiang Zhang, Jacquelynn J. Cook, Marie A. Holahan, Maria T. Stranieri, Gary R. Sitko, S. Lee Gaul, Rodney A. Bednar, Bohumil Bednar, George D. Hartm

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 264 KB

english, 1997

18

Chemical modification of chalcone isomerase by diethyl pyrocarbonate: Histidine residues are not essential for catalysis

Rodney A. Bednar, Adejare J. Adeniran

Journal:

Archives of Biochemistry and Biophysics

Year:

1990

Language:

english

File:

PDF, 612 KB

english, 1990

19

Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation

Egbertson, Melissa S., Cook, Jacquelynn J., Bednar, Bohumil, Prugh, John D., Bednar, Rodney A., Gaul, Stanley L., Gould, Robert J., Hartman, George D., Homnick, Carl F., Holahan, Marie A., Libby, Laur

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 12 KB

english, 1999

20

Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

Dr. Paul J. Coleman, John D. Schreier, Dr. Christopher D. Cox, Michael J. Breslin, David B. Whitman, Dr. Michael J. Bogusky, Dr. Georgia B. McGaughey, Dr. Rodney A. Bednar, Wei Lemaire, Dr. Scott M. D

Journal:

Year:

2012

Language:

english

File:

PDF, 445 KB

english, 2012

21

Synthesis, characterization, and reactions of 2′-, 3′-, and 5′-(2-bromoethyl)-AMP: Potential affinity labels for nucleotide binding sites in enzymes

Rodney A. Bednar, Roberta F. Colman

Journal:

The Protein Journal

Year:

1982

Language:

english

File:

PDF, 1.21 MB

english, 1982

22

3-Bromo-2-ketoglutarate: a substrate and affinity label for DPN-dependent isocitrate dehydrogenase

Bednar, Rodney A., Hartman, Fred C., Colman, Roberta F.

Journal:

Year:

1982

Language:

english

File:

PDF, 1.15 MB

english, 1982

23

Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)

Philippe G Nantermet, James C Barrow, George F Lundell, Janetta M Pellicore, Kenneth E Rittle, MaryBeth Young, Roger M Freidinger, Thomas M Connolly, Cindra Condra, Jerzy Karczewski, Rodney A Bednar,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 129 KB

english, 2002

24

Discovery of the Dual Orexin Receptor Antagonist [(7 R )-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2 H -1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Cox, Christopher D., Breslin, Michael J., Whitman, David B., Schreier, John D., McGaughey, Georgia B., Bogusky, Michael J., Roecker, Anthony J., Mercer, Swati P., Bednar, Rodney A., Lemaire, Wei, Brun

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.38 MB

english, 2010

25

Intramolecular proton transfer through water in diamine monocations

Bednar, Rodney A., Jencks, William P.

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 526 KB

english, 1985

26

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists

Ian M. Bell, Rodney A. Bednar, John F. Fay, Steven N. Gallicchio, Jerome H. Hochman, Daniel R. McMasters, Cynthia Miller-Stein, Eric L. Moore, Scott D. Mosser, Nicole T. Pudvah, Amy G. Quigley, Christ

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 173 KB

english, 2006

27

Is hydrocyanic acid a normal acid? Proton transfer from hydrocyanic acid to bases and small inhibition of proton exchange by acid

Bednar, Rodney A., Jencks, William P.

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 1.28 MB

english, 1985

28

Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility

Michael R. Wood, Kathy M. Schirripa, June J. Kim, Amy G. Quigley, Craig A. Stump, Ian M. Bell, Rodney A. Bednar, John F. Fay, Joseph G. Bruno, Eric L. Moore, Scott D. Mosser, Shane Roller, Christopher

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 251 KB

english, 2009

29

Introduction of unnatural amino acids into chalcone isomerase

Bednar, Rodney A., McCaffrey, Catherine, Shan, Kaiyu

Journal:

Bioconjugate Chemistry

Year:

1991

Language:

english

File:

PDF, 868 KB

english, 1991

30

Automation of In Vitro Dose-Inhibition Assays Utilizing the Tecan Genesis and an Integrated Software Package to Support the Drug Discovery Process

Mosser, Scott D., Gaul, Stanley L., Bednar, Bohumil, Koblan, Kenneth S., Bednar, Rodney A., Bednar, Rodney A.

Journal:

Journal of the Association for Laboratory Automation

Year:

2003

Language:

english

File:

PDF, 1.93 MB

english, 2003

31

Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors

Melissa S Egbertson, Bohumil Bednar, Ben C Askew, Rodney A Bednar, Karen Brashear, Michael J Breslin, Mark E Duggan, Thorsten E Fisher, Wasyl Halczenko, John H Hutchinson, Nathan Ihle, John D Prugh, J

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 174 KB

english, 2000

32

Reactivity and pH dependence of thiol conjugation to N-ethylmaleimide: detection of a conformational change in chalcone isomerase

Bednar, Rodney A.

Journal:

Year:

1990

Language:

english

File:

PDF, 879 KB

english, 1990

33

Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists

Layton, Mark E., Kelly, Michael J., Rodzinak, Kevin J., Sanderson, Philip E., Young, Steven D., Bednar, Rodney A., DiLella, Anthony G., Mcdonald, Terrence P., Wang, Hao, Mosser, Scott D., Fay, John F.

Journal:

ACS Chemical Neuroscience

Year:

2011

Language:

english

File:

PDF, 1.28 MB

english, 2011

34

Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs)

Mercer, Swati P., Roecker, Anthony J., Garson, Susan, Reiss, Duane R., Meacham Harrell, C., Murphy, Kathy L., Bruno, Joseph G., Bednar, Rodney A., Lemaire, Wei, Cui, Donghui, Cabalu, Tamara D., Tang,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.06 MB

english, 2013

35

Arginine-Glycine-Aspartic Acid Mimics Can Identify a Transitional Activation State of Recombinant αIIbβ3 in Human Embryonic Kidney 293 Cells

Abraham, Dicky G., Nutt, Elka M., Bednar, Rodney A., Bednar, Bohumil, Gould, Robert J., Duong, Le T.

Journal:

Molecular Pharmacology

Year:

1997

Language:

english

File:

PDF, 698 KB

english, 1997

36

Nonpeptide glycoprotein IIb/IIIa inhibitors: 18. Indole alpha-sulfonamide acids are potent inhibitors of platelet aggregation

Karen M. Brashear, Jacquelynn J. Cook, Bohumil Bednar, Rodney A. Bednar, Robert J. Gould, Wasyl Halczenko, Marie A. Holahan, Robert J. Lynch, George D. Hartman, John.H. Hutchinson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 343 KB

english, 1997

37

Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on an N,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats

David B. Whitman, Christopher D. Cox, Michael J. Breslin, Karen M. Brashear, John D. Schreier, Michael J. Bogusky, Rodney A. Bednar, Wei Lemaire, Joseph G. Bruno, George D. Hartman, Duane R. Reiss , C

Journal:

Year:

2009

Language:

english

File:

PDF, 418 KB

english, 2009

38

Proline bis-amides as potent dual orexin receptor antagonists

Jeffrey M. Bergman, Anthony J. Roecker, Swati P. Mercer, Rodney A. Bednar, Duane R. Reiss, Richard W. Ransom, C. Meacham Harrell, Douglas J. Pettibone, Wei Lemaire, Kathy L. Murphy, Chunze Li, Thomaya

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 196 KB

english, 2008

39

Direct proton transfer between hydrocyanic acid and nitrogen and oxygen bases

Bednar, Rodney A., Jencks, William P.

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 1.16 MB

english, 1985

40

In vitro characterization of novel NR2B selective NMDA receptor antagonists

Laszlo Kiss, Gong Cheng, Bohumil Bednar, Rodney A. Bednar, Paul B. Bennett, Stefanie A. Kane, Charles J. McIntyre, John A. McCauley, Kenneth S. Koblan

Journal:

Neurochemistry International

Year:

2005

Language:

english

File:

PDF, 478 KB

english, 2005

41

Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists

Askew, Benny C., Bednar, Rodney A., Bednar, Bohumil, Claremon, David A., Cook, Jacquelynn J., McIntyre, Charles J., Hunt, Cecila A., Gould, Robert J., Lynch, Robert J., Lynch,, Joseph J., Gaul, Stanle

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 289 KB

english, 1997

42

Direct proton transfer between hydrocyanic acid and nitrogen and oxygen bases. [Erratum to document cited in CA103(25):214716g]

Bednar, Rodney A., Jencks, William P.

Journal:

Journal of the American Chemical Society

Year:

1993

Language:

english

File:

PDF, 142 KB

english, 1993

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